Indian installment - chemical composition and pharmacological effect

Indian installment - chemical composition and pharmacological effect

Costus is a well-known plant and has been used to treat many health problems since ancient times, such as: immune inflammatory diseases, ulcers, asthma, and stomach problems, as it was found that the main active substances in costum are Sesquiterpenoid lactones

Many studies on experimental animals and humans have shown the effectiveness of this plant in treating many diseases.

The chemical composition of the Indian costum plant (roots):

1. Terpenes

2. Flavonoids

3. Other components such as phytosterols

The medicinal effect of Indian premium:

1. An anti-ulcer effect of the stomach and duodenum, where a root extract solution was given at a concentration of 200-300 mg/kg of body weight to experimental animals that were given (alcohol with aspirin) to generate stomach ulcers, so the role of the root extract was stronger than ranitidine.

2. Anti-cancer:

Where it was found that some of the active substances in the Indian premium gave an effect that prevents the growth of cancer cells, these substances are:

  Alantolactone, Caryophyllene, Costic acid, Costunolide, and Dehydrocostuslactone

Laboratory studies have been conducted on three types of cancer cells, which are colon, breast and lung cancer, as it shows the clear effect of the Indian costum extract in killing these cancer cells.

Other studies have shown the strong effect of Indian Costus extracts in preventing the growth and spread of aggressive breast cancer.

3. Anti-inflammatory effect:

Laboratory studies were carried out on white cells of experimental animals and measured the percentage of nitrogen monoxide as well as TNF-α and the effect of costus extract on them, where the results were positive. This is an indication of its role in treating joint diseases, rheumatic and inflammatory diseases in general.

4. Antibacterial effect

Where it was found that the alcoholic extracts of the roots of the Indian costum have an antidote to many harmful bacteria that cause many health problems for humans, such as respiratory and urinary system infections, intestinal infections, typhoid, and others: such as:

    Bacillus cereus (ATCC11778), Staphylococcus epidermidis (ATCC12228), Enterobacter aerogenes (ATCC13048), Proteus vulgaris (NCTC 8313), Salmonella typhimurium (ATCC 23564).

Perhaps this was the reason for the benefit that patients felt during the Corona pandemic by using the Indian installment.

Other studies have also shown the role of extracts of Indian premium anti-tuberculosis Mycobacterium tuberculosis, and this opens a wonderful door for treating intractable and difficult cases of this disease along with other medicines.

5. Costus Benefits in Protecting Liver Tissue:

Studies were conducted on experimental animals where hepatitis was generated by some chemicals, so that liver enzymes were clearly elevated compared to control animals. However, when the extract of Indian costum was used, the levels of enzymes decreased and gave a preventive effect to the deterioration of the condition of the liver.

These results give an indication of the effect of the Indian knotweed in hepatoprotective activity, and they confirm what the medical heritage has said about the benefits of the Indian knotweed in liver diseases.

6. Immune modulatory effect:

It was found that strong doses of Indian premium (more than 250 mg / kg weight) lead to modification of the immune system, whether at the cellular level or immunity in general. This is evidence of the benefit of the Indian premium in many immune diseases such as asthma, rheumatism, lupus fever, multiple sclerosis, and others.

7. The effect of installment on the circulatory system and the heart:

A study was carried out on the hearts of experimental animals using the Langendorff's technique, where the heart rate, systolic force, and blood flow in the coronary arteries were recorded through different concentrations of the methanolic extract of St. John's wort compared to digoxin and diltiazem. the heart.

8. The effect of Indian premium on epilepsy

It was found that the alcoholic extract of Indian costum has a clear positive anti-convulsive and anti-epileptic role on experimental animals whose brain impulses were generated by electrical stimulation and through some chemicals such as Pentylenetetrazole

9. Indian premium and its effect in reducing the level of harmful cholesterol

It was found that the alcoholic extract of Indian costum reduced triglycerides and raised the level of beneficial HDL cholesterol in the blood.